Titlebook: RNA and DNA Diagnostics; Volker A. Erdmann,Stefan Jurga,Jan Barciszewski Book 2015 Springer International Publishing Switzerland 2015 DNA

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Mechanochemical Sensing,cognizes an analyte, the accompanied change in the tension of the template can be monitored in real time. This chapter discusses the general principle of the mechanochemical sensing, the pros and cons of this new sensing scheme, as well as future prospects for this strategy.

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DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics,xes play an important role in sensing the Hg presence in the environment. This chapter encompasses different concepts and methods showing the coherence between the structure, composition, and electronic properties of DNA and RNA.

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Electrochemical Biosensors for miRNA Detection,y 22 nucleotides in length) that act as regulators of protein translation. Because many diseases are caused by the misregulated activity of proteins, miRNAs have been implicated in a number of diseases including a broad range of cancers, heart disease, and immunological and neurological diseases. A

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Electrochemical Detection of RNA, expression. This chapter focuses on different electrochemical detection approaches of RNA with applications in clinical diagnostics as well as in food and environmental analysis. Electrochemical biochips are an emerging tool for point-of-care diagnostic systems due to their inherent high sensitivit

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Aptamers in Oncotherapy,s for their use as potential drugs, probes, or delivery agents. In this chapter, we will cover three novel biological applications incorporating the use of aptamers in therapeutics. First, we will discuss the most recent advancements in the use of these short oligonucleotides for targeted delivery o

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Genotyping of Single Nucleotide Polymorphisms,ociated with diseases such as cardiovascular diseases, different types of cancer, and other genetic diseases. As such, SNPs are currently considered as potentially important cancer biomarkers that may significantly improve cancer diagnosis and prognosis, aid drug development, and offer personalized

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Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-Modified Oligonucleotide the dansyl-ONTs specifically increased in the presence of adjacent guanosine residues but significantly reduced in a dansyl-flipping duplex. These changes were caused by a solvatochromism effect—which was governed by the number of guanine molecules, which are hydrophobic—and the external environmen