Titlebook: RNA and Cancer; Jane Y. Wu Book 2013 Springer-Verlag Berlin Heidelberg 2013 Alternative splicing.Cell death.Imaging.Microarray.Tumor

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The Perinucleolar Compartment: RNA Metabolism and Cancer, RNA processing proteins and several RNA pol III transcripts, which form novel complexes. As determined by cell culture experiments and human tumor samples, the PNC forms exclusively in cancer cells and the percentage of cancer cells in a population that have one or more PNCs directly correlates wit

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Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer, large class of mammalian mRNAs is regulated by AU-rich elements (AREs) located in the mRNA 3′ UTRs. mRNAs with AREs are inherently labile but as a response to different cellular cues they can become either stabilized, allowing expression of a given gene, or further destabilized to silence their exp

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Alternative Pre-mRNA Splicing, Cell Death, and Cancer,ng gene activities at the post-transcriptional level. Alternative splicing plays important roles in regulating genes critical for cell death. These cell death genes encode death ligands, cell surface death receptors, intracellular death regulators, signal transduction molecules, and death executor e

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Oligonucleotide Therapeutics in Cancer,ugs that manipulate gene expression and improve the disease state. Antisense oligonucleotides hybridize with a target mRNA to downregulate gene expression via an RNase H-dependent mechanism. Additionally, RNase H-independent splice switching oligonucleotides (SSO) modulate alternative or aberrant sp

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Clinical Perspective on Chemo-Resistance and the Role of RNA Processing,he potential to be used as cancer biomarkers and also as targets for new therapeutic approaches. In addition, the cancer-specific transcripts have the potential to alter the drug response of the cancer cells creating a chemo-resistant state. This later property of alternative splicing presents a cha

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Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray,se the utilization of microarray in detecting alternatively processed RNAs, which have alternative splice forms, retained introns, or altered 3′ untranslated regions. We cover the methodology and focus on cancer studies. Recent development in parallel or deep sequencing used in transcriptome analysis is also discussed.

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Oligonucleotide Therapeutics in Cancer,sion via an RNase H-dependent mechanism. Additionally, RNase H-independent splice switching oligonucleotides (SSO) modulate alternative or aberrant splicing, to favor the therapeutically relevant splicing product. This chapter summarizes the progress made in the application of these oligonucleotide drugs in the treatment of cancer.

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