Titlebook: RNA Interference and CRISPR Technologies; Technical Advances a Mouldy Sioud Book 2020 Springer Science+Business Media, LLC, part of Springe

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Chemical Modifications in RNA Interference and CRISPR/Cas Genome Editing Reagents, as continual efforts are being made to optimize ON efficacy. Over the years, RNA interference (RNAi) has become one of the main tools used to inhibit RNA expression across a wide variety of species. Efforts have been made to improve the exogenous delivery of the double-stranded RNA components to th

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Preparation, Determination of Activity, and Biodistribution of Cholesterol-Containing Nuclease-Resiw molecular weight drugs. Despite significant progress in this area, the potential for therapeutic use of RNAi in humans is limited due to the lack of efficient delivery systems. Bioconjugation is one of the most promising methods for delivering siRNA to cells and tissues, since conjugation of siRNA

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Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy,rating with other therapeutics; however, transporting siRNA and other active ingredients to the same location at the same time is challenging. Here, we report a novel multifunctional nanodelivery platform by sequentially layering several functional ingredients, such as siRNAs, microRNAs, peptides, a

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Delivery of Functional Small RNAs via Extracellular Vesicles In Vitro and In Vivo,EVs have recently gained significant interest as a promising material for delivery of therapeutics. Small RNAs, including small interfering RNA (siRNA) and microRNA (miRNA), provide a great therapeutic strategy for treating human diseases. However, it remains a challenge to deliver unconjugated smal

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