Titlebook: RNA Activation; Long-Cheng Li Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singap

考博

DNR215

不自然

BUDGE

NADIR

Enhancing Neuronogenesis and Counteracting Neuropathogenic Gene Haploinsufficiencies by RNA Gene Actrotherapeutic strategies. Among these there is the stimulation of select histogenetic subroutines for purposes of cell-based brain repair, as well as the therapeutic treatment of gene expression deficits underlying severe neurological disorders..We employed RNA activation (RNAa) to transactivate the

Ointment

Target-Recognition Mechanism and Specificity of RNA Activationtranscription, a phenomenon known as RNA activation (RNAa). RNAa is distinct from the established RNAi mechanistic framework, although AGO2 is required by both. The precise mechanism of RNAa is currently disputable and has become a bottleneck in the development of this new technology. saRNA may achi

entrance

Promoter-Targeted Small Activating RNAs Alter Nucleosome Positioningtivating RNAs (saRNAs), but it is unclear how the chromosomal environment influences gene expression. In a study of the activation of the OCT4, SOX2, and NANOG genes by saRNAs, we found that saRNA targeting induced nucleosome-depleted region (NDRs) and the accumulation of RNA polymerase II (RNAPII)

外星人

Endogenous miRNAa: miRNA-Mediated Gene Upregulation expressed small activating RNA has been demonstrated in different cellular contexts by a number of laboratories. Conceivably, endogenously expressed microRNAs may also utilize RNA activation as a cellular mechanism for gene regulation, which may be dysregulated in disease states such as cancer. RNA

一美元

miRNA-Mediated RNA Activation in Mammalian Cellsught to primarily down regulate gene expression by binding to 3′ untranslated regions of target transcripts, thereby triggering mRNA cleavage or repression of translation. Recently, evidence has emerged that miRNAs can interact with the promoter and activate gene expression. This mechanism, called R

狼群

RNAa Induced by TATA Box-Targeting MicroRNAsingly, our group identified a novel HIV-1-encoded miRNA, miR-H3, which targets specifically the core promoter TATA box of HIV-1 and activates viral gene expression. Depletion of miR-H3 significantly impaired the replication of HIV-1. miR-H3 mimics could activate viruses from CD4. T cells isolated fr