Titlebook: RAS Family GTPases; Channing Der Book 2006 Springer Science+Business Media B.V. 2006 Activation.Endoplasmatisches Reticulum.biochemistry.c

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Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic s now well-appreciated that Ras induces an immensely complicated network of signaling cascades that can lead to very different outcomes depending on cell type, genetic background, phenotype assayed for, and so forth. On top of all these differences, mounting evidence suggests that there may even be

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Genetically Engineered Mice Harboring RAS Mutations as Models of Human Cancer: in Medias RAS,y, introducing . mutations as transgenes under the control of a heterologous promoter was shown to cause neoplastic changes where expressed, proving . the relevance of . mutations to cancer. Lesions usually developed after a long latent period, and the additional mutation of tumor suppressor genes (