Titlebook: Quantitative Physiology; Systems Approach Shangbin Chen,Alexey Zaikin Book 2020 Huazhong University of Science and Technology Press 2020 Qu

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Complex and Surprising Dynamics in Gene Regulatory Networkspear. Here we show how clustering and oscillation death can appear in a system of coupled repressilators, how cellular decision making can depend on speed in noisy genetic networks, and how one can implement genetic intelligence.

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tions.Sets a paradigm for quantitative physiology by integra.Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Com

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Modelling Gene Expressionill-type equations and, using this methodological framework, explain how gene expression provides production of a protein at a permanent concentration, genetic oscillations, or a genetic switch to enable a switching between two epigenetic states.

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Calcium Signallingl [..]. and .. in endoplasmic reticulum [..].. Then we introduce the simulation of spontaneous .. oscillations in astrocytes mediated by voltage-gated calcium channels. Also, we briefly review the models of calcium waves and show one example.