Titlebook: Quantitative Decisions in Drug Development; Christy Chuang-Stein,Simon Kirby Book 20171st edition Springer International Publishing AG 201

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Medley

清真寺

condemn

作嘔

wall-stress

The Parallel Between Clinical Trials and Diagnostic Tests,fference between statistical power and the probability of a positive trial. This last point becomes more important as a new drug moves through the various development stages as will be illustrated in Chap. 9.

jeopardize

Incorporating Information from Completed Trials in Future Trial Planning,ities under some definitions of success. We can use simulations to estimate these probabilities when close-form expressions do not exist. With the use of prior distributions for the parameters of interest, we show how to assess the positive and negative predictive values of a design with its companion decision rule.

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Designing Phase 4 Trials,o consider a trial comparing a drug against a comparator using information obtained from the network meta-analysis. We also discuss how prior distributions for treatment effects may be obtained by other means such as PK/PD modeling.

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