Titlebook: Quantile Regression in Clinical Research; Complete analysis fo Ton J. Cleophas,Aeilko H. Zwinderman Textbook 2021 The Editor(s) (if applica

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Discrete Trend Testing Versus Quantile Regression multiple drugs from one class with different potencies, or different formulas from one drug with various bio-availabilities and other pharmacokinetic properties. In such situations small differences in efficacies are to be expected, and we need, particularly, sensitive tests. A standard approach to

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Binary Poisson/Negative Binomial Regressions Versus Quantileby the first treatment performed better than the second although hardly at a significant level. Binary Poisson analysis in Generalized Linear Models provided a slightly better p-values of 0.039. As alternative to binary Poisson, the closely related negative binomial model was used. It produced the s

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Optimal Scaling Versus Quantile Regressioncan be scored on different outcome scales between 0 and 10. Often the relationship between outcome and predictor can be optimized in order for the predictor to better fit the outcome. Optimal scaling can be replaced or supplemented with quantile regressions. In the data example of this chapter the b