| 書(shū)目名稱(chēng) | Protein Conformational Dynamics | | 編輯 | Ke-li Han,Xin Zhang,Ming-jun Yang | | 視頻video | http://file.papertrans.cn/762/761650/761650.mp4 | | 概述 | Covering both the description of widely used theoretical approaches and the applications of these methods in the study of protein dynamics.A thorough and extensive exploration and description of recen | | 叢書(shū)名稱(chēng) | Advances in Experimental Medicine and Biology | | 圖書(shū)封面 |  | | 描述 | This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in?this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression..?.On the experimental side, the technical advances have offered deep insights into the co | | 出版日期 | Book 2014 | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-02970-2 | | isbn_softcover | 978-3-319-35389-0 | | isbn_ebook | 978-3-319-02970-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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