| 書目名稱 | Proteases in Physiology and Pathology | | 編輯 | Sajal Chakraborti,Naranjan S. Dhalla | | 視頻video | http://file.papertrans.cn/762/761557/761557.mp4 | | 概述 | Offers a comprehensive investigation into the regulation of proteases and their pathological consequences.Explores the specific inhibitors and molecular probes for proteases to improve therapy for var | | 圖書封面 |  | | 描述 | .Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development..This in-depth, comprehensive is avaluable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical | | 出版日期 | Book 2017 | | 關(guān)鍵詞 | Protease and Antiproteases; Neuronal Diseases; Cancer; Cardiovascular Diseases; Parasitic Diseases; Gene | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-10-2513-6 | | isbn_softcover | 978-981-10-9636-5 | | isbn_ebook | 978-981-10-2513-6 | | copyright | Springer Nature Singapore Pte Ltd. 2017 |
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