| 書目名稱 | Protease Inhibitors as Cancer Chemopreventive Agents | | 編輯 | Walter Troll,Ann R. Kennedy | | 視頻video | http://file.papertrans.cn/762/761542/761542.mp4 | | 圖書封面 |  | | 描述 | Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and p | | 出版日期 | Book 1993 | | 關(guān)鍵詞 | carcinogenesis; cell; cell membrane; enzymes; prevention; synthesis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-2882-1 | | isbn_softcover | 978-1-4613-6249-4 | | isbn_ebook | 978-1-4615-2882-1 | | copyright | Springer Science+Business Media New York 1993 |
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