| 書目名稱 | Prostaglandin E1 | | 副標(biāo)題 | New Aspects on Pharm | | 編輯 | Curt Diehm,Helmut Sinzinger,Waltraud Rogatti | | 視頻video | http://file.papertrans.cn/762/761466/761466.mp4 | | 圖書封面 |  | | 描述 | Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour- able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi- 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given int | | 出版日期 | Conference proceedings 1991 | | 關(guān)鍵詞 | Lipoprotein; Prostaglandin E1; Verschlu?krankheit; blood; cardiovascular; cardiovascular system; circulati | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-76910-8 | | isbn_softcover | 978-3-540-54524-8 | | isbn_ebook | 978-3-642-76910-8 | | copyright | Springer-Verlag Berlin Heidelberg 1991 |
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