| 書目名稱 | Progress in Hormone Biochemistry and Pharmacology | | 編輯 | Michael Briggs,Alan Corbin | | 視頻video | http://file.papertrans.cn/761/760504/760504.mp4 | | 叢書名稱 | Progress in Hormone Biochemistry | | 圖書封面 |  | | 描述 | Somatostatin was discovered in 1971, by Guillemin and his colleagues during their search for the hypothalamic growth hormone-releasing factor. A peptide was found in ovine hypothalamus which inhibited the release of growth hormone from cultured anterior pituitary cells. 1,2 Determination 3 of its amino acid sequence indicated that it was a tetradecapeptide with a molecular weight of 1639 (Figure lJ. An identical peptide was later isolated from porcine hypothalamus by Schally and his coworkers. 4 The peptide was named somatostatin in the belief that it was a hypothalamic releasing factor whose sole function was to inhibit the secretion of growth hormone. It soon became evident, however, that a peptide with identical immunologic characteristics and biologic activity was present in the D cells of pancreatic islets, in D-like cells of the gastrointestinal tract, in parafollicular cells of the thyroid gland, and in extrahypo- thalamic neurons of both the central and peripheral nervous system in various species, including man. Moreover, studies employing synthetic somatostatin5 demonstrated that the peptide possessed a wide spectrum of biologic activities in addition to its inhibition of | | 出版日期 | Book 1980 | | 關(guān)鍵詞 | biochemistry; pharmacology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-011-7712-2 | | isbn_softcover | 978-94-011-7714-6 | | isbn_ebook | 978-94-011-7712-2 | | copyright | Eden Press Incorporated 1980 |
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