| 書目名稱 | Principles of Cancer Treatment and Anticancer Drug Development | | 編輯 | Wolfgang Link | | 視頻video | http://file.papertrans.cn/756/755483/755483.mp4 | | 概述 | Explains in easy-to-understand language, how current medicines against cancer work and how we find new ones for interested readers and students.It includes the most updated options to treat cancer and | | 圖書封面 |  | | 描述 | This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND)and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of d | | 出版日期 | Textbook 2019 | | 關(guān)鍵詞 | drug discovery; preclinical drug development; targeted therapy; chemotherapy; clinical trials; antibacter | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-18722-4 | | isbn_softcover | 978-3-030-18724-8 | | isbn_ebook | 978-3-030-18722-4 | | copyright | Springer Nature Switzerland AG 2019 |
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