| 書目名稱 | Phosphodiesterase Methods and Protocols | | 編輯 | Claire Lugnier | | 視頻video | http://file.papertrans.cn/747/746349/746349.mp4 | | 概述 | Includes supplementary material: | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | The multigenic family of cyclic nucleotide phosphodiesterases (PDEs) is now known to offer many new therapeutic possibilities through their influence over intracellular signaling, though their precise cell mechanisms to modulating that process remain uncertain. In Phosphodiesterase Methods and Protocols, a panel of research leaders in the PDE field describes new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatiotemporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonstrate not only the potential role of targeted PDEs, but also their use in further studies of the central role of PDE regulation in intracellular signaling control. These techniques offer clinicians a way to find new therapies for numerous pathologies whose molecular origins are unkno | | 出版日期 | Book 2005 | | 關(guān)鍵詞 | Calcium; Escherichia coli; Filtration; Lipid; Nucleotide; Promoter; Termination; genes; hybridization | | 版次 | 1 | | doi | https://doi.org/10.1385/1592598390 | | isbn_softcover | 978-1-61737-487-6 | | isbn_ebook | 978-1-59259-839-7Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2005 |
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