| 書(shū)目名稱(chēng) | Phase Separation in Living Cells | | 副標(biāo)題 | Benefits and Risks | | 編輯 | Riki Kurokawa | | 視頻video | http://file.papertrans.cn/746/745776/745776.mp4 | | 概述 | A multidisciplinary approach to phase separation from physics, chemistry, molecular biology, biology and medicine.Presents a novel view on phase separation control and aggregations.Analyzes neurodegen | | 圖書(shū)封面 |  | | 描述 | .This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine..Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus..Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase se | | 出版日期 | Book 2023 | | 關(guān)鍵詞 | Phase separation; Aggregation; intrinsically disordered protein; membrane-less organelle; nuclear pore c | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-99-4886-4 | | isbn_softcover | 978-981-99-4888-8 | | isbn_ebook | 978-981-99-4886-4 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
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