Titlebook: Paraoxonase (PON1) in Health and Disease; Basic and Clinical A Lucio G. Costa,Clement E. Furlong Book 2002 Springer Science+Business Media

organic-matrix

CHD and Atherosclerosis: Human Epidemiological Studies and Transgenic Mouse Models,tivities. Polymorphisms of the PON1 gene, including the promoter region polymorphism, T(-107)C, and the coding region polymorphisms, L55M and Q192R, have been associated with coronary heart disease (CHD) in case-control studies of various populations, indicating PON1 may be a genetic factor that inf

同謀

considerable

歌曲

PON1 and Organophosphate Toxicity,the hypothesis that individuals with low PON1 activity may be at higher risk from toxic effects due to exposure to organophosphorus (OP) insecticides. Evidence that this may be the case has been obtained from a number of animal studies. First, animal species with low serum PON1 activity (e.g. birds)

警告

Factorable

Perspectives in PON1 Research,such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups accepted this point (see Chapter 1). In more recent years more has become known about the natural

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PON1 Polymorphisms, of specific OP substrates. Other polymorphisms have been described in the 5’ and 3’ non-coding regions. Several of the 5’ polymorphisms may influence serum PON1 levels that in turn affect rates of substrate hydrolysis.

闖入

Protective Action of HDL-Associated PON1 Against LDL Oxidation,revents these events and the inverse relation between HDL and atherosclerotic events may in part be due to enzymes associated with HDL that destroy the biologically active lipids generated in LDL. The potential role of one of these enzymes, paraoxonase 1 (PON1) is discussed below.

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Victoria H. Brophy,Gail P. Jarvik,Clement E. Furlong Was jedoch seit dem Ende der 80er- Jahre Bestand hat und in unserem Kontext den Mittelpunkt jeder prozessbezogenen Strategie darstellt, ist die Verwaltung von Wissen in verschiedenen Softwaretools und Datenbanken.