| 書目名稱 | PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics | | 編輯 | Mukesh Nandave,Priti Jain | | 視頻video | http://file.papertrans.cn/741/740340/740340.mp4 | | 概述 | Explores potentials of PROTAC-based therapies in combating cancer.Covers all aspects related to PROTACs, including history, mechanisms, design, and clinical development.Defines the concept of a fundam | | 圖書封面 |  | | 描述 | .This book is a comprehensive coverage of the ubiquitin-proteasome system and its involvement in cancer progression, and the application of PROTACs in different types of cancer treatment. The book discusses a unique perspective and comprehensive knowledge of the potential of PROTACs to transform cancer therapies. It provides an overview of the history, mechanisms, chemistry, design considerations, and different technologies involved in PROTACs. Additionally, it explains the ubiquitin-proteasome system, its impact on various diseases, and the principles and mechanisms of UPS. The book also describes the chemistry and design aspects of PROTACs and their role in various types of cancers. Finally, it covers the pharmaceutics aspect of formulation design, global requirements, and toxicological aspects of PROTACs. This book is targeted at cancer researchers, medical oncologists, bioinformatics, computational biologists, pharmacologists, medicinal chemists, formulation scientists, regulatory authorities, and policy makers.. | | 出版日期 | Book 2024 | | 關(guān)鍵詞 | Proteasome system to target destruction of proteins; PROTAC in clinical applications; Translational in | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-97-5077-1 | | isbn_softcover | 978-981-97-5079-5 | | isbn_ebook | 978-981-97-5077-1 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
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