Titlebook: Oxidative Stress and Vascular Disease; John F. Keaney (Associate Professor of Medicine an Book 2000 Springer Science+Business Media New Yo

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Sean Davies,Thomas McIntyre,Stephen Prescott,Guy Zimmermanactors responsible for the human "disease" produced by uric acid in the joints and kidneys. The final four chapters provide a summary of therapeutic approaches 978-3-642-66869-2978-3-642-66867-8Series ISSN 0171-2004 Series E-ISSN 1865-0325

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0166-9842 othelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, th978-1-4613-7103-8978-1-4615-4649-8Series ISSN 0166-9842

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John F. Keaney (Associate Professor of Medicine an

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Sources of Vascular Oxidative Stresss an elevated concentration of low density lipoprotein (LDL), the major carrier of blood cholesterol (1). It is thus paradoxical that LDL often fails to exert atherogenic effects .. These observations led to the suggestion that LDL has to be modified to promote vascular disease (2,3). Subsequent stu

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Antioxidant Defenses in the Vascular Walling on its extent and duration, and the type of oxidant(s) involved. Within the vascular wall both radicals (., one electron) and nucleophilic (two electron) oxidants are likely produced and contribute to oxidative stress (see Chapter 2). This chapter describes antioxidant defenses in the vascular w

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