Titlebook: Osteoimmunology; Yongwon Choi Conference proceedings 2007 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spri

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Interaction with Estrogen Receptors as Treatment of Arthritis and Osteoporosis, on bone. Estrogen exerts its effects via activation of its two receptors ERα and ERβ. Our knowledge of how estrogen manages to mediate its various properties in different organs has increased tremendously by studies of ER targeted mice (Matthews and Gustafsson 2003; Hewitt, Harrell and Korach 2005)

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The Enigmatic Function of TREM-2 in Osteoclastogenesis,eloid cells. TREM-2 is expressed on macrophages, microglia and pre-osteoclasts and transduces intracellular signals through the adaptor DAP12. In human, genetic defects of TREM-2 and DAP12 result in a rare syndrome characterized by presenile dementia and bone cysts. This syndrome and the tissue dist

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Role of Cell-matrix Interactions in Osteoclast Differentiation,Analysis of tissues from sites of bone resorption reveal that cells expressing the full morphological and functional properties of mature osteoclasts are restricted to the immediate bone surface. We hypothesize that in addition to cytokines, components of the bone matrix and specific cell surface re

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Positive and Negative Roles of IL-6, STAT3, and SOCS3 in Inflammatory Arthritis,n, development of pannus, progressive cartilage destruction and bone erosion. Although the cause of RA remains unknown, it has been suggested that cytokines, especially proinflammatory cytokines such as tumor necrosis factor α(TNF-α), interleukin (IL)-1, and IL-6 derived from activated synovial cell

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