Titlebook: Organic Cation Transporters; Integration of Physi Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlat Book 2016 Springer International Publi

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Introduction to the Cellular Transport of Organic Cations,llular drug delivery and, considering their high expression in excretory organs, together with MATEs are responsible for drug excretion. For this reason, OCTs and MATEs can be important determinants of drug efficacies and also toxicities. OCTNs are transporters involved in the cellular uptake of sub

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Functional Properties of Organic Cation Transporter OCT1, Binding of Substrates and Inhibitors, and of tertiary structures that were modeled according to lactose permease which belongs to the MFS. Considering rOCT1 and rOCT2 as OCT prototypes, and assuming that all transporters of the MFS undergo similar interhelical movements during transport, a model for the translocation mechanism of OCTs is p

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Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Dru cisplatine or oxaliplatin were affected by substrate specificities of renal OCT2 and MATEs. OCTs and MATEs play important roles for drug efficacies and toxicities especially in the liver and the kidney.

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Translational Relevance of Animal Models for the Study of Organic Cation Transporter Function,ty, levels of mRNA and/or protein expression, sensitivity to inhibitors, and regulation. In comparison with animal models, in the human organs some OCTs are absent, others exhibit different localization in the cell membrane domains and different levels of expression, sensitivity to inhibitors, and r

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Role of Transporters for Organic Cations in Plants for Environmental Cycling of Pharmaceutical Resis. Due to the large number of pharmaceuticals present in the environment, it is important to understand the uptake and translocation mechanisms involved that can lead to accumulation of biological active compounds in feed and food.