Titlebook: Oral Delivery of Macromolecular Drugs; Barriers, Strategies Andreas Bernkop-Schnürch Book 2009 Springer-Verlag New York 2009 Barriers.Bernk

粗俗人

bypass

Low Molecular Mass Permeation Enhancers in Oral Delivery of Macromolecular Drugs,permeation enhancers in mind and taking all the opportunities ahead into consideration, this class of permeation enhancers will certainly further alter the landscape of drug delivery towards more efficient therapeutic systems.

CUMB

Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery,n provide high drug concentrations at the target site and tight contact with the absorption membrane due to mucoadhesion. Furthermore, sustained or delayed release due to cohesive properties of the polymeric carrier system offers new possibilities for targeted macromolecular drug delivery.

要素

Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules,n) was observed after oral administration. In most cases, the polymer-coated liposomes and/or polymer–liposome complexes showed superior pharmacological action compared to other systems without mucoadhesive polymers.

OATH

Nano- and Microparticles in Oral Delivery of Macromolecular Drugs,ilicity. Particles’ properties such as membrane-passing properties, permeation-enhancing properties, mucoadhesive properties, and protective properties are extensively discussed. Furthermore, evidence for the potential of such systems is provided with examples from recent in vivo studies.

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Bph773

Book 2009ther advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could

Encoding

Gastrointestinal Mucus Gel Barrier, the usefulness of orally administered drugs. In this chapter, I review the molecular and cellular properties of gel-forming mucins and how these macromolecules are organized into a tri-dimensional network to form the gastrointestinal mucus gel barrier.

asthma

Strategies to Overcome Efflux Pumps,everal drugs across the intestine..In this chapter, several efflux pump inhibitors such as low molecular mass inhibitors, polymeric inhibitors and advanced formulation approaches on how to overcome drug efflux are discussed.

神刊

Strategies in Oral Immunization,s is one approach which enables the production of highly customized all-in-one self-adjuvanting vaccines. Lipid-modified peptide vaccines have been successfully investigated in humans and demonstrated to be potent and more importantly very safe.