Titlebook: Oral Delivery of Macromolecular Drugs; Barriers, Strategies Andreas Bernkop-Schnürch Book 2009 Springer-Verlag New York 2009 Barriers.Bernk

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Strategies to Overcome the Enzymatic Barrier,e regarded as one main reason for their poor bioavailability after peroral administration. Within the current chapter, strategies to overcome the so-called enzymatic barrier are described. Besides formulations that can protect the drug from enzymatic digestion via, e.g., drug encapsulation and chemi

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Strategies to Overcome Efflux Pumps,tics, antivirals, calcium channel blockers, immunosuppressive agents, peptide drugs and several other therapeutic compounds have been reported to be substrates of one or more transmembrane efflux transporters..Inhibition of these efflux pumps by various compounds can lead to enhanced absorption of s

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