Titlebook: Optical Imaging of Brain Function and Metabolism 2; Physiological Basis Arno Villringer,Ulrich Dirnagl Book 1997 The Editor(s) (if applica

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978-1-4899-0058-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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The MR ,, Based Perfusion ModelThere are a number of theoretical and practical questions one needs to consider to understand and optimize contrast to noise of the versatile .. based perfusion model. We made an evaluation of the several popular .. based methods currently applied to measure flow and flow change.

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Towards Near-Infrared Imaging of the BrainSeveral methods have been employed in attempts to estimate atraumatically the in-vivo cerebral blood flow and metabolism. One approach is to measure brain hemoglobin oxygen-saturation level and blood volume in vivo by using near-infrared reflection or transmission spectroscopy.

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Is There a Different Type of MR-Contrast in the Early Phase of Functional Activation?ase in the oxyhemoglobin concentration of the activated areas, which can be observed by susceptibility sensitive MR imaging techniques such as echo planar imaging (2) or gradient echo imaging with long echo times (3).

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Cerebral Oxygenation States as Revealed by Near-Infrared Spectrophotometryitoring of tissue oxygenation. However, even now the quantification of hemoglobin signals and the knowledge of the redox behavior of cytochrome oxidase in vivo, as well as the measurement of cytochrome in the presence of normal blood circulation still pose unresolved issues.

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