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Titlebook: Oncogenes as Transcriptional Regulators; Cell Cycle Regulator M. Yaniv,J. Ghysdael Book 1997 Springer Basel AG 1997 Cancerogenes.Onkogenese

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發(fā)表于 2025-3-21 17:43:54 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Oncogenes as Transcriptional Regulators
副標題Cell Cycle Regulator
編輯M. Yaniv,J. Ghysdael
視頻videohttp://file.papertrans.cn/702/701363/701363.mp4
叢書名稱Progress in Gene Expression
圖書封面Titlebook: Oncogenes as Transcriptional Regulators; Cell Cycle Regulator M. Yaniv,J. Ghysdael Book 1997 Springer Basel AG 1997 Cancerogenes.Onkogenese
描述The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character- ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro- teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral- lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper- toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel- opment concerns tumor s
出版日期Book 1997
關鍵詞Cancerogenes; Onkogenese; Zellbiologie; cancer; cancer research; cell; cell biology; chromosome; genes; lymph
版次1
doihttps://doi.org/10.1007/978-3-0348-8934-6
isbn_softcover978-3-0348-9833-1
isbn_ebook978-3-0348-8934-6
copyrightSpringer Basel AG 1997
The information of publication is updating

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發(fā)表于 2025-3-21 22:53:20 | 只看該作者
Book 1997f 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character-
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fication of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically
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Signalling to the C-terminus of p53,domain of p53 resides in its conserved central region. However, several studies have revealed that the C-terminal portion of p53 can regulate sequence-specific binding by the central domain. Here we review published experiments that have addressed the relationship between the C-terminal and central
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Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleested they play a fundamental role in the initiation and/or progression of the tumorigenic process. Among these rearrangements, over a hundred different balanced and reciprocal translocations have been described, mainly in hematopoietic malignancies and mesenchymal tumors (Mitelman, 1994). Over the
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ht oder nur mit einem Stich gen?ht werden müssen. Die L?nge variiert also vom kleinen Einstich mit der Her Klinge bis zu einer L?nge von einem knappen Zentimeter. Der Durchschnitt liegt bei ca. 0,5 cm. Das Instrumentarium hierfür besteht aus . und den dazugeh?rigen Klemmchen. Beide gibt es in versch
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