Titlebook: Oncogenes and Growth Control; Patricia Kahn,Thomas Graf Book 1986 Springer-Verlag Berlin Heidelberg 1986 ATP.Activation.Colon.DNA.Interleu

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Introductionoth to normal cells, in which growth is tightly controlled, as well as to cancer cells, which divide in an uncontrolled fashion. Molecular and biochemical studies have led to the identification of a number of genes whose products are involved in regulating normal cell growth. In addition, many genes

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Glycogen

A Role for Proto-Oncogenes in Differentiation?lecular and cellular biology. To date more than 30 different c-. genes are known which encode proteins localized in the nucleus or cytoplasm, are associated with the plasma membrane or even secreted (see Table 1). It has been presumed from the outset that proto-oncogenes play a role in growth contro

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Tissue-Specific Expression and Possible Functions of pp60, ler; Beug et al.; Sherr and Stanley; Heldin and Westermark, all this Vol.), the function of the c-. protein pp60. has remained an enigma despite the fact that it was the very first proto-oncogene product identified (Collett et al. 1978). The difficulty in studying pp60. is that it occurs at a very l

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The Granulocyte-Macrophage Colony-Stimulating Factorsich comprise eight distinct cellular lineages. In normal health, the circulating levels of mature cells are remarkably invariant, suggesting that their production is tightly regulated. However, the haemopoietic system is also flexible, allowing fluctuations in the levels of various cell types to mee

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Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cellst to play a role in mitogenesis. It is therefore likely that the viral oncogene products stimulate uncontrolled cell proliferation by subverting the mitogenic pathway at key regulatory points. An indication that similar mechanisms may operate in nonviral cell transformation comes from the old observ

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GRIEF

Transforming Growth Factor-, to the receptor for epidermal growth factor (EGF) and thereby inhibits the binding of EGF. Subsequent examination showed that this factor is made by many other transformed cell lines but not by adult normal cells in culture (Todaro et al. 1985). Addition of sarcoma growth factor, as it was first cal

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