Titlebook: Oncogenes Meet Metabolism; From Deregulated Gen G. Kroemer,D. Mumberg,K. Petersen Conference proceedings 2008 Springer-Verlag Berlin Heidel

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0947-6075 cts on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics)..978-3-642-09840-6978-3-540-79478-3Series ISSN 0947-6075

Dissonance

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The Interplay Between MYC and HIF in the Warburg Effect, concurrent decrease in mitochondrial respiration. Target genes that are common to both HIF and MYC, such as PDK1, LDHA, HK2, and TFRC, are therefore attractive therapeutic targets, because their coordinate induction by HIF and MYC widens the therapeutic window between cancer and normal tissues.

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Using Metabolomics to Monitor Anticancer Drugs, of such drugs in early-phase clinical trials. This review focuses on the use of ex vivo NMR and in vivo MRS methods for monitoring the effect of some novel anticancer drugs on the cancer metabolome. Ex vivo NMR methods are complementary to in vivo measurements, as they can provide additional inform

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Minimally Invasive Biomarkers for Therapy Monitoring, the minimally invasive WIN method for measuring tumour interstitial pressure (IFP). The data show that drug-induced changes in IFP (ΔIFP) involve mechanism-dependent changes in the tumour vascular architecture, and that ΔIFP may be considered a?universal generic early-response marker of tumour resp

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