Titlebook: Oncogenes; Christopher Benz,Edison Liu Book 1989 Kluwer Academic Publishers 1989 DNA.Staging.cancer treatment.leukemia.lymphoma.molecular

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Oncogenes978-1-4613-1599-5Series ISSN 0927-3042 Series E-ISSN 2509-8497

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The platelet-derived growth factor system) play equally important roles in normal developmental and pathological processes, as well as in the genesis of certain neoplasms. In this respect, the PDGF system is appropriately considered within the broader context of human oncogenes.

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Oncogenes in human solid tumorsummarize those concepts pertinent to oncogene activation that might help in understanding the present evidence supporting a role for oncogenes in the development or progression of naturally occurring human tumors.

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Oncogenes and proto-oncogenes: General conceptsts that probably play some role in normal cell proliferation and differentiation are called proto-oncogenes. Genetic alterations (such as proviral insertional mutations, chromosomal translocation, gene amplification, or point mutations) can activate cellular oncogenes that in turn contribute to neoplasia.

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