Titlebook: Oncogene-Induced Senescence; Methods and Protocol Mikhail A. Nikiforov Book 2017 Springer Science+Business Media New York 2017 Senescent ce

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Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy, likely determines the quality of the phenotype (Pérez-Mancera et al., Nat Rev Cancer 14:547–558, 2014). Autophagy, a cellular degradation process, has been proposed to be one of these senescence effectors, although its functional relevance seems highly context dependent (Hoare et al., Semin Cancer

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Sudan Black B, The Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent als. Lipofuscin is related to many ageing processes. It is also known to accumulate in senescent cells. We recently proved that lipofuscin detection, when applying the SBB staining, is highly specific for the visualization of senescent cells. Here, we present in detail this SBB method that can detec

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Detection of Reactive Oxygen Species in Cells Undergoing Oncogene-Induced Senescence, radical (O.°.), hydroxyl radical (OH°.); but also nonradical molecule like hydrogen peroxide (H.O.). ROS play a critical role in several physiological functions like proliferation and signalling pathways. Thanks to cellular (oxidant/antioxidant) systems, ROS level is tightly regulated to avoid exce

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Senescence-Like Phenotypes in Human Nevi,li. Senescence is a critical and potent defense mechanism that mammalian cells use to suppress tumors. While there are many ways to induce a senescence response, oncogene-induced senescence (OIS) remains the key to inhibiting progression of cells that have acquired oncogenic mutations. In primary ce

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Detection of Oncogene-Induced Senescence In Vivo, suggested to function as a cancer cell intrinsic mechanism to restrain tumor growth and has been implicated as a key mechanism preventing the progression of certain premalignant lesions in genetically engineered mouse models of cancer. The senescent phenotype can be defined by two criteria that inc