Titlebook: Oncogene-Directed Therapies; Janusz Rak Book 2003 Springer Science+Business Media New York 2003 angiogenesis.cell.gene therapy.metastasis.

VEIL

Oncogenic Receptor Tyrosine Kinaseshormones, which penetrate through the plasma membrane due to their hydrophobic character, these factors must bind a cell surface-localized receptor. In contrast to multispan receptors for neuropeptides and chemical transmitters, growth factor receptors transverse the plasma membrane only once, and t

Minatory

Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis stimulation of a wide spectrum of cell surface receptors, converge on and activate Ras .. Activated Ras, in turn, interacts with a multitude of downstream effector targets to initiate functionally diverse cytoplasmic signaling pathways .. Many of the cytoplasmic signaling components that function u

Abrupt

insolence

Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment can provide a selective pressure for the expansion of populations of oncogenically transformed rodent cells with reduced apoptotic sensitivity, not only to hypoxia ., but to chemotherapeutic agents as well ..

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Mawkish

CUR

Oncogenes and Tumor Angiogenesismulus for studies on oncogenes .. Although this approach proved to be very powerful in establishing the genetic causes of cancer, it was in itself insufficient to properly interpret the resulting complexity of the unfolding pathological process .. Indeed, cancer as a disease involves a multitude of

Arrhythmia

磨坊

The Impact of Oncogenes on Tumor Maintenancee number, chromosomal translocation, and gene amplifications .. These alterations result in a gain of function of oncogenes and a loss of function of tumor suppressor genes, leading to uncontrolled growth, differentiation, and apoptosis. The number of mutations required for a tumor to develop in hum

Perigee

Primary and Secondary Events in Oncogene-Driven Tumor Development mouse models of tumor development offer the means to reproducibly isolate different stages of tumor progression, which then are amenable to pathological, genetic, and biochemical analyses. Moreover, tumor cell lines derived from the different tumor stages are useful tools in experimentally addressi