Titlebook: Of Fish, Fly, Worm, and Man; Lessons from Develop Christiane Nüsslein-Volhard,J?rn Kr?tzschmar Conference proceedings 2000 Springer-Verlag

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, Smad1 , Smad5 ,,succession of cell cleavages, cell specifications, and morphogenetic events which are strictly coordinated temporally and spatially, and which within two days lead to a larva that very much resembles the adult fish. Important morphogenetic processes occur during gastrulation when the embryo becomes

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Genetic Dissection of Heart Development,1994). Lacking a vertebrate model system for large-scale genome-wide screens has limited a direct genetic approach toward vertebrate pattern formation in the past. Luckily, gene functions and pathways are often conserved from invertebrates to vertebrates and studying these pathways has been fruitful

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Eph Receptors and Ephrins Are Key Regulators of Morphogenesis,to generate the tissues and layers of the forming body. The molecular basis of the control of morphogenesis is not well understood. The Eph receptors and their ligands the ephrins, represent a cellular signalling system that is important for the correct enactment of morpho-genetic processes in the v

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,The Indian Hedgehog — PTHrP System in Bone Development,tramembranous ossification in which mesenchymal cells directly differentiate into osteoblasts. The second mechanism, called endochondral ossification, is used to form the bones of the axial and appendicular skeleton as well as some of the facial bones. Endochondral ossification (Erlebacher et al. 19

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0947-6075 ow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-scale" biology, the study of the function of genes and the interactions between their protein products. The aim of the Ernst Schering Research Fou

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Eph Receptor Tyrosine Kinases and Their Ligands in Development,rins, chemorepulsion by Netrins and secreted Semaphorins; contact-mediated attraction by Ig domain-containing cell adhesion molecules (Ig-CAMs), Cadherins, and extracellular matrix proteins (ECM); and finally, contact-mediated repulsion by transmembrane Semaphorins, ECM proteins, and Ephrins (Tessier-Lavigne and Goodman 1996; Müller 1999).