Titlebook: Nuclear Receptors: From Structure to the Clinic; Iain J. McEwan,Raj Kumar Book 2015 Springer International Publishing Switzerland 2015 NMR

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Christopher J. Millard,John W. R. Schwabeork of Alfred Lord Tennyson and Gerald Manley Hopkins.Offers.In this updated second edition renowned amateur comet-searcher David H. Levy?expands on his work about the?intricate relationship between the night sky and the works of English Literature.?This revised and expanded text includes new sectio

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Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic,ematic representation of nuclear receptors, based on biochemical studies, to crystal and NMR structures of the isolated ligand binding and DNA binding domains, which have increased our understanding of receptor structure and provided fresh insights into function. Recent progress has seen the emergen

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Vital-Signs

Glucocorticoid Receptor Structure and Function the level of gene regulation by binding to the glucocorticoid receptor (GR). The phenomenon of hormone-dependent activation of the GR has extensively been exploited for the clinical evolution of small molecule selective glucocorticoid receptor modulators. Current understanding of the available stru

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Endemic

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Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptoreptor (EcR) and Ultraspiracle (Usp). Upon dimerization EcR and Usp recognize the ecdysteroid response elements (EcREs) present in promoter regions of the ecdsysteroid-responsive genes. Detailed structural analyses of EcR and Usp DNA binding domains revealed that each protein contributes in different

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Custodian

Primate-Specific Multi-Functional Androgen Receptor Coregulator and Proto-Oncogene Melanoma Antigen-stosterone or dihydrotestosterone. AR transcriptional activity is modulated by the androgen-dependent NH.- and carboxyl-terminal (N/C) interaction between the AR NH.-terminal F.LF motif and the activation function 2 surface of the ligand binding domain. The N/C interaction stabilizes AR and modulate

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