Titlebook: Nuclear Receptors; The Art and Science Mostafa Z. Badr Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Design of Novel PPAR Agonist for Neurodegenerative Disease, these partial agonists have been observed to show a favorable impact on insulin sensitivity, blood glucose levels, and dyslipidemia with significantly reduced side effects on human health. Partial agonists have been found to display differences in transcriptional and cellular outcomes by acting thr

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Androgen Receptors in the Pathology of Disease,cal conditions related to AR dysfunction involve altered levels of androgens and structural alterations in the AR. These include mutations, polymorphisms in the polyglutamine tract of the NTD, and alternative splicing of AR to yield constitutively active receptors. From the extensive list of AR-rela

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,Bilirubin: A Ligand of the PPARα Nuclear Receptor,other PPAR isoforms PPARβ/δ and PPARγ, and how they function to control peroxisomes and mitochondria that mediates fatty acid β-oxidation and adiposity. There may be clinical interest in bilirubin-PPARα functionality to rectify NAFLD and insulin resistance in the obese.

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Nuclear Receptor Ligands in Flavivirus Infection Control,est that antagonizing these receptors increases the susceptibility to viral infection. On the other hand, liver X receptors (LXRs) that are involved in cholesterol homeostasis may play a role in flavivirus infection control. LXR agonists have shown to inhibit viral replication via activating cholest