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Titlebook: Nuclear Receptors; The Art and Science Mostafa Z. Badr Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license

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發(fā)表于 2025-3-21 18:22:49 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Nuclear Receptors
副標題The Art and Science
編輯Mostafa Z. Badr
視頻videohttp://file.papertrans.cn/669/668679/668679.mp4
概述Covers how produced modulators are evaluated experimentally and eventually in relevant disease states, before reaching the phase of developing more efficient and/or less toxic therapies.Explains how s
圖書封面Titlebook: Nuclear Receptors; The Art and Science  Mostafa Z. Badr Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license
描述Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases..This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins.?World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address?the various means and consequences of modulating nuclear receptor activity will be presented and discussed.?These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through ca
出版日期Book 2021
關(guān)鍵詞molecular pharmacology; drug design; PPAR; PXR; metabolic diseases; vitamin d receptor; ligand; target tran
版次1
doihttps://doi.org/10.1007/978-3-030-78315-0
isbn_softcover978-3-030-78438-6
isbn_ebook978-3-030-78315-0
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 22:57:37 | 只看該作者
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Multifaceted Effects of Ligand on Nuclear Receptor Mobility,partments and in their intranuclear dynamics. This chapter highlights key features of three main categories of intracellular localization into which the nuclear receptors can be roughly sorted: ligand-dependent nuclear accumulation, ligand-dependent intranuclear localization, and ligand-independent trafficking.
地板
發(fā)表于 2025-3-22 08:38:27 | 只看該作者
Pregnane X Receptor: Understanding Its Function and Activity at the Molecular Level,tain diseases, such as inflammatory bowel disease. This book chapter describes the molecular basis of PXR activity, correlating biochemical and structural elements to describe the promiscuous nature of PXR in recognizing a wide array of chemicals and the challenges in developing PXR modulators.
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,PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview,ntify common ligand design factors for selectivity towards a PPAR subtype. Methods to improve drug-lead identification and optimization and other factors that may contribute to design of a successful PPAR ligand are discussed.
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Use of Nanotechnology to Improve 15d-PGJ2 Immunomodulatory Activities,we focus on how 15d-PGJ. is involved in the resolution of inflammatory responses and as potential analgesic molecule. Importantly, we will present evidences that nanotechnology (nanocarriers) is a helpful tool to improve its action and bioavailability.
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發(fā)表于 2025-3-23 04:58:12 | 只看該作者
ng more efficient and/or less toxic therapies.Explains how sNuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological co
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發(fā)表于 2025-3-23 06:05:09 | 只看該作者
978-3-030-78438-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
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