Titlebook: Novel Technologies for Vaccine Development; Igor S Lukashevich,Haval Shirwan Book 2014 Springer-Verlag Wien 2014 infectious disease.preven

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978-3-7091-1980-8Springer-Verlag Wien 2014

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Viral-Vectored Vaccines to Control Pathogenic Filovirusesften fatal disease in humans and nonhuman primates. Pathogenic Marburg and Ebola viruses are endemic in resource-poor regions in Central Africa and are also of concern as they have the potential for deliberate misuse. Although no vaccines or antiviral drugs for filoviruses are currently available fo

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Alphavirus Replicon Vectors for Prophylactic Applications and Cancer Interventionce of an alphaviral structural polyprotein. Because viral structural genes are missing, replicon RNA cannot initiate replication of an alphavirus. However, due to the presence of intrinsic RNA-dependent RNA polymerase activity, replicons are capable of self-amplification in vitro and in vivo resulti

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Current Status of Hantavirus Vaccines Developmentn the Americas. These viruses are carried by persistently infected rodents and are transmitted to humans by aerosolized rodent excreta. The number of reported cases of hantavirus infection is growing in many countries. New hantavirus strains have been increasingly isolated worldwide raising public-h

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