Titlebook: Novel Chemical Tools to Study Ion Channel Biology; Christopher Ahern,Stephan Pless Book 2015 The Editor(s) (if applicable) and The Author(

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Obvious

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indignant

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https://doi.org/10.1007/978-1-4939-2845-3Biophysics; Bioreactivity; Fluorometry; Ion Channels; Modifications; Proteins

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Introduction,ng of this pore can be controlled by a myriad of physiological inputs (voltage, ligands, temperature, metabolites, pH), which in turn allow for the controlled flux of ions across membranes, resulting in the generation of minute electrical signals. The functional implications of ion channel function

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Cysteine Modification: Probing Channel Structure, Function and Conformational Change,embrane proteins in their native environment, embedded in phospholipid membranes. Among the 20 amino acids, cysteine is uniquely reactive. This reactivity has motivated the synthesis of a wide array of sulfhydryl reactive chemicals. The commercially available array of sulfhydryl reactive reagents ha

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Functional Site-Directed Fluorometry,rected fluorometry has since been expanded to numerous other voltage-gated and ligand-gated ion channels as well as transporters, pumps, and other integral membrane proteins. The power of functional site-directed fluorometry, also known as voltage-clamp fluorometry, lies in its ability to provide in