Titlebook: Novel Approaches to Treatment of Osteoporosis; R. Graham G. Russell,Timothy M. Skerry,Uwe Kollenk Conference proceedings 1998 Springer-Ver

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The Identification and Isolation of Cells of the Osteoblast Lineage in Cultures of Adult Human Bones due to a reduction in the number of osteoblasts. It has been proposed that this same mechanism is a major cause of bone loss in all other forms of osteoporosis (Parfitt 1990a, b, 1992; Cohen-Solal et al. 1991; Compston et al. 1989; Jilka et al. 1996).

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Apoptosis in Bone Cells,ation of lactation and leads to the associated reduction in breast size, and shrinkage of prostatic tissue after orchidectomy occurs by a similar mechanism (Reed 1994). Because bone is a hormonally sensitive tissue, it is possible that apoptosis of bone cells could be a major determinant of bone sha

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Genetics in Osteoporosis,shown to be risk factors for osteoporosis. In fact, the relative risk of osteopenia was higher in individuals with a father with osteoporosis: 2.16 compared to individuals with a mother suffering from osteoporosis (Soroko et al. 1994).

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The Regulation of Gene Expression in Bone by Mechanical Loading,regimens for improvement of bone mass. In addition it has become clear from clinical studies that exercise which fails to increase bone mass may still reduce the risk of fractures in osteoporotic individuals. This is because the increased muscle power and coordination which accompany increased fitne