Titlebook: Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate; Yves Christen,Alain Isra?l,Frédéric Checler Conference proceedings 200

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,βAPP Processing, its Biology and Alzheimer’s Disease,c function remains enigmatic. In this paper I propose a model in which processing of APP, under control of presenilins, generates an intracellular peptide that regulates the cellular threshold to apoptosis.

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Conference proceedings 2002ative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early

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