Titlebook: Notch Signaling in Embryology and Cancer; Molecular Biology of J?rg Reichrath,Sandra Reichrath Book 2020Latest edition The Editor(s) (if ap

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Regulation of Notch Signaling in ,: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 as involvement in numerous developmental events, Notch signaling requires tight spatial and temporal regulation. Deltex is a cytoplasmic protein that physically binds to the Notch and regulates its signaling activity in a context-dependent manner. However, the biology of Deltex in regulation of Notch

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Interaction of Long Noncoding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss,ommonly impacts tissue homeostasis, being highly associated with proliferative disorders. The long noncoding RNAs (lncRNAs), which are transcripts with more than 200 nucleotides that do not code for proteins, were already described as Notch signaling pathway-interacting molecules. Many of them act a

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Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Among the flag-ship Notch functions we could mention its capacity to keep precursor and stem cells in a nondifferentiated state but also its ability to activate cell proliferation that in some contexts could led to cancer. In general, both these functions involve, canonical, ligand-dependent Notch a

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,Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond,ic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1–4), and each of them plays nonredundant functions at s

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Laura Marquez-Exposito,Elena Cantero-Navarro,Raúl R. Rodrigues-Diez,Macarena Orejudo,Antonio Tejera-ause it must be in a position to forcibly deter aggressors in order to protect its citizens. Citizens want their governments to have the power to protect them, but this same power can be used against them too. Much of the analysis in previous chapters has been devoted to seeing how the government ca

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