Titlebook: Notch Signaling Research; Methods and Protocol Dongyu Jia Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genal characterization of variants in these “genes of unknown significance” continues to increase. In this chapter, we describe a workflow to functionally characterize a rare variant in a Notch signaling related gene that was found to be associated with late-onset Alzheimer’s disease. This pipeline in

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bution within such limits as may be prescribed by law’. It provides, finally, for parliamentary democracy of the traditional western variety where socialists and non- socialists, the exploiter and the exploited, have equal rights but unequal opportunities to seek election and grab power.