Titlebook: Notch Regulation of the Immune System; Freddy Radtke Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Notch Signaling During Human T cell Development, signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse.

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The Role of Notch in the Differentiation of CD4+ T Helper Cells,wever, the exact mechanisms involved remain unclear and appear contradictory. In this review, we summarize current knowledge and discuss recent advances in the field to reconcile different views on the role of Notch signaling in the differentiation of functional T helper subsets.

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Book 2012vances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system.? This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia..

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0070-217X ietic and the immune system.? This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia..978-3-642-43408-2978-3-642-24294-6Series ISSN 0070-217X Series E-ISSN 2196-9965

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0070-217X ocesses during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. Thi