Titlebook: Non-coding RNAs in Colorectal Cancer; Ondrej Slaby,George A. Calin Book 2016 The Editor(s) (if applicable) and The Author(s), under exclus

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Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions often engaged in double-negative feedback loops forming bistable switches controlling the transitions from epithelial to the mesenchymal cell states. Within this chapter, we will provide a comprehensive overview over the transcription factors and microRNAs that have been implicated in the regulatio

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Non-coding RNAs Functioning in Colorectal Cancer Stem Cellseatures that have been widely referred to stem cells. The same pathways have been identified in colorectal cancer stem cells (CRCSCs), conferring a more aggressive phenotype compared to non-stem CRC cells. Recently, several evidences suggested that non-coding RNAs (ncRNAs) may play a crucial role in

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Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectalariants could plausibly impact miRNA expression and target mRNA translation into proteins critical for cellular integrity, differentiation, and proliferation..In the present chapter, we describe the different aspects of variations related to miRNAs and other non-coding RNAs (ncRNAs) and evidence fro

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Non-coding RNAs Enabling Prognostic Stratification and Prediction of Therapeutic Response in Colorecin addition to individual patient tumor phenotyping and other validated genetic markers, could facilitate the prediction of risk of progression in CRC patients and help assess overall survival. Recent findings point to the emerging role of non-protein-coding regions of the genome in their contributi

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