Titlebook: Non-canonical Cyclic Nucleotides; Roland Seifert Book 2017 Springer International Publishing AG 2017 bacterial toxins.cyclic nucleotides.m

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,3′,5′-cIMP as Potential Second Messenger in the Vascular Wall,egarded as true “second messengers” in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3′,5′‐cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response

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,Discovery and Roles of 2′,3′-cAMP in Biological Systems,in the renal venous perfusate from isolated, perfused kidneys detected a large signal at the same m/z transition (330 → 136) as 3′,5′-cAMP but at a different retention time. Follow-up experiments demonstrated that this signal was due to a positional isomer of 3′,5′-cAMP, namely, 2′,3′-cAMP. Soon the

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8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy,in the presence of reactive oxygen species (ROS), reacts with biomolecules to produce nitrated cGMP derivatives. 8-Nitro-cGMP was the first endogenous cGMP derivative discovered in mammalian cells (2007) and was later found in plant cells. Among the six nitrogen atoms in this molecule, the one in th

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Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides,c monophosphate (cCMP) and uridine 3′,5′-cyclic monophosphate (cUMP) have been hampered by the lack of highly specific and sensitive analytic methods for these analytes. In addition, the existence of 2′,3′-cNMP besides 3′,5′-cNMP has been described recently. HPLC coupled with tandem mass spectrometr

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