Titlebook: Non-Natural Nucleic Acids; Methods and Protocol Nathaniel Shank Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 201

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,Synthesis and Application of LKγT Peptide Nucleic Acids,th high precision and accuracy provides a distinct advantage over other ligand-display systems, such as polymers, because the number and position of the ligand(s) can be accurately and fully characterized. Here we describe the synthesis of peptide nucleic acids (PNAs), which are oligonucleotide mimi

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Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids,obes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly manipulate amino sugar (neomycin, kanamycin) to more powerful and selective ligands are presented in this chapter. We describe representative procedures for (a) aminoglycoside conjugation and (b) prel