Titlebook: Non-Functional Requirements in Software Engineering; Lawrence Chung,Brian A. Nixon,John Mylopoulos Book 2000 Springer Science+Business Med

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Lawrence Chung,Brian A. Nixon,Eric Yu,John Mylopoulos levels of phosphorylated p38, a canonical MKP-1 target previously associated with maintenance of tumor dormancy. These results elucidate a novel angiogenesis-driven mechanism involving the Notch and MAPK pathways that controls tumor dormancy. More in general, angiogenic EC could form part of the va

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Lawrence Chung,Brian A. Nixon,Eric Yu,John Mylopoulos therapy. One important mechanistic insight into tumor dormancy is that oncogene addiction might involve regulation of a decision between self-renewal and cellular senescence. Recent evidence suggests that this decision is regulated by multiple mechanisms that include tumor cell-intrinsic, cell-auto

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Lawrence Chung,Brian A. Nixon,Eric Yu,John Mylopoulos cells to survive and thrive in this microenvironment is of vital interest. In this chapter, we discuss the intravascular microenvironment that the circulating tumor cells must endure. We summarize the current experimental and computational literature on tumor cells in the circulation system. We als

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oxygen and nutrient distribution can be obtained and a plethora of therapeutic protocols can be tested before clinical trials. This chapter provides an overview over the current status of computer simulations of vascular remodeling during tumor growth including interstitial fluid flow, drug delivery

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Lawrence Chung,Brian A. Nixon,Eric Yu,John Mylopoulosous biomolecules. Here we summarize the methodology for Raman imaging of alkyne-tagged bioactive small molecules in living biological systems including the development of slit-scanning Raman microscope, which is useful for fast imaging of alkyne-tagged molecules.

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Lawrence Chung,Brian A. Nixon,Eric Yu,John Mylopoulosial to expand the spectrum of questions asked about the cell, and to further clarify the physical nature of animate matter and motion.978-1-4614-6882-0978-1-4614-6883-7Series ISSN 2193-097X Series E-ISSN 2193-0988