Titlebook: Nitric Oxide: From Research to Therapeutics; Arunabha Ray,Kavita Gulati Book 2023 The Editor(s) (if applicable) and The Author(s), under e

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Translating Nitric Oxide Research to Therapeutics: A Critical Appraisal,rious effects arising from inflammation-related excessive NO levels. NO-deficient states are characterized by cell senescence, oxidative stress, inflammation, endothelial dysfunction and insulin resistance. In sepsis, NO synthesis is dysregulated leading to cardiovascular dysfunction, bioenergetic f

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Role of Nitric Oxide Synthases in Doxorubicin-Induced Cardiomyopathy,. More recently, our laboratory and others have also shown the importance of nitrosative stress. Furthermore, we have shown that Vitamin C not only mitigates nitrosative stress but it also modulates Dox-induced cardiotoxic changes in isolated cardiomyocytes as well as in whole animals exposed to Dox