Titlebook: Nitric Oxide and the Kidney; Physiology and Patho Michael S. Goligorsky,Steven S. Gross Book 1997 Springer Science+Business Media Dordrecht

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Metabolic Pathways and Cycles of L-Arginine Synthesis and Utilizationne, and polyamines and influences the release of hormones and the synthesis of pyrimidine bases [1]. Arginine was identified and isolated from proteins more than a century ago [23]. It was not until the 1930s that its prominent role in normal metabolism began to unfold. This chapter summarizes avail

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Distribution of NOSs in the Kidneysoforms NOS I also termed neurona I (n) or brain (b) type NOS based on its first identification in the brain of various speciesl and NOS III or endothelial (ec) NOS, although this isoform is not solely expressed in endothelia but has now also been detected in epithelial cells, see below], and the in

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Role of NO in the Function of the Juxtaglomerular Apparatusus. The constituents of this cell complex are epithelial, interstitial, and modified smooth muscle cells. The epithelial cells of the JGA are located at the distal end of the thick ascending limbs, a part of the nephron that always returns to the vascular pole of its parent glomerulus. The tubular c

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NOS in Mesangial Cells: Physiological and Pathophysiological Rolesoinflammatory features of intrinsic mesangial cells evolve as a result of the cross-talk with invading professional immune cells: (i) increased mediator production, (ii) increased matrix production by mesangial cells, and (iii) increased mesangial cell proliferation [1]. Resting mesangial cells do n

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NO and The Renin Systemity of the renin—angiotensin system in the circulation is mainly dependent on the activity of the protease renin, which is considered the key regulator of the system. Renin found in the circulation comes predominantly from the kidneys, where renin is produced primarily by the so-called juxtaglomerul

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