Titlebook: Nitric Oxide and the Cardiovascular System; Joseph Loscalzo,Joseph A. Vita Book 2000 Springer Science+Business Media New York 2000 biochem

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Nitric Oxide and Pulmonary Hypertensionated. Pathophysiologic states that perturb the normal control of pulmonary artery blood pressure result in significant clinical manifestations. The discovery of the central role of the nitric oxide (NO.) signal transduction system in the regulation of pulmonary arterial tone in health and disease ha

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Cell and Molecular Biology of Nitric Oxide Synthasesequence similarities to archetypal reductases from plants and bacteria. The N-terminal domain, variably termed the heme or oxygenase domain, shows significant sequence similarities only among the three members of the NOS family, and contains the site for binding of the enzymes’ heme prosthetic group

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Cellular Signal Transduction and Nitric Oxideso be mediated by other proteins whose activities are allosterically modified by cGMP (e.g., phosphodiesterases and ion channels), and via cross-activation of cAMP-dependent kinase (protein kinase A [PKA]). This chapter will cover NO.’s specific effects on signaling pathways in vascular smooth muscl

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Nitric Oxide and Pulmonary Hypertensiontaining basal pulmonary vascular tone; (5) the role of NO. in modulating acute hypoxic pulmonary vasoconstriction; (6) the role of NO. in chronic pulmonary hypertension; (7) abnormalities of NO. production in human disease; and (8) the use of NO. and NO.-donor compounds for the diagnosis and treatme

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