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Titlebook: Nicotine and Related Alkaloids; Absorption, distribu J. W. Gorrod,J. Wahren Book 1993 Springer Science+Business Media Dordrecht 1993 Oxidat

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書目名稱Nicotine and Related Alkaloids
副標(biāo)題Absorption, distribu
編輯J. W. Gorrod,J. Wahren
視頻videohttp://file.papertrans.cn/667/666432/666432.mp4
圖書封面Titlebook: Nicotine and Related Alkaloids; Absorption, distribu J. W. Gorrod,J. Wahren Book 1993 Springer Science+Business Media Dordrecht 1993 Oxidat
描述Nicotine is an alkaloid which is present, together with a number of minor alkaloids, in tobacco and a wide variety of other plants. The introduction of tobacco as a therapeutic agent against diverse pathologi- cal and physiological conditions resulted in the widespread exposure of people to nicotine, and the subsequent recognition of the pleasurable effects of tobacco consumption. Tobacco may be used for pleasure by smoking it in pipes, cigars or cigarettes or by taking it in unsmoked form as oral and nasal tobacco snuff. Nonsmokers are exposed to nico- tine through plant material and side-stream tobacco smoke. This means that in humans nicotine is always utilized in the presence of a very large variety of natural compounds or their pyrolysis products, depend- ing on the route of administration. These compounds may modify the absorption, distribution, metabolism and excretion of nicotine and hence alter the duration of its pharmacological action. In recent years the use of nicotine in chewing gum and cutaneous patches has been developed as an aid to smoking cessation. The toxic properties of nicotine make it useful as an insecticide, which has led to its use in agriculture and hort
出版日期Book 1993
關(guān)鍵詞Oxidation; absorption; alkaloids; enzyme; enzymes; kinetics; metabolism; methylation; pharmacokinetics; resea
版次1
doihttps://doi.org/10.1007/978-94-011-2110-1
isbn_softcover978-94-010-4936-8
isbn_ebook978-94-011-2110-1
copyrightSpringer Science+Business Media Dordrecht 1993
The information of publication is updating

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Pharmacokinetics of (,)-nicotine and metabolites in humans,owitz .., 1990). Metabolites of nicotine may be pharmacologically active (Clark .., 1965) or may be toxic (Shigenaga ..,1988) and, therefore, it is important to know levels of human exposure. Metabolic data can be used to estimate nicotine intake and exposure to tobacco smoke (Benowitz, 1984; Benowitz and Jacob, 1984a).
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The metabolic fate of the minor tobacco alkaloids,t 2200 components have been separated from tobacco plant extracts (Schmeltz and Hoffman, 1977) and almost 500 compounds in tobacco smoke have been characterized by gas chromatographic techniques (Schumacher .., 1977).
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oduction of tobacco as a therapeutic agent against diverse pathologi- cal and physiological conditions resulted in the widespread exposure of people to nicotine, and the subsequent recognition of the pleasurable effects of tobacco consumption. Tobacco may be used for pleasure by smoking it in pipes,
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policy perspective to discuss sustainable agricultural develThis book provides a non-technical, accessible primer onsustainable agricultural development and its relationship to sustainabledevelopment based on three analytical pillars. The first is to understandagriculture as complex physical-biologi
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