Titlebook: Next Generation Kinase Inhibitors; Moving Beyond the AT Paul Shapiro Book 2020 Springer Nature Switzerland AG 2020 kinase inhibitors.ATP bi

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Protein Kinase Interactions with Regulatory and Effector Proteins,m plasma membrane receptors through the cell to cause changes in gene expression and cellular responses. This chapter will take a closer look at the interactions between protein kinases and their substrates and interacting partners. Despite the well-conserved organization of the ATP-binding and -cat

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Developing Kinase Inhibitors Using Computer-Aided Drug Design Approaches, is an introduction of well-established and newly developed computer-aided drug design (CADD) approaches that are regularly being used in the development of kinase inhibitors. This includes methods from the two major CADD categories: structure-based drug design (SBDD) and ligand-based drug design (L

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Novel Stabilized Peptide Inhibitors of Protein Kinases,ity among kinases within the additional flanking domains and sequences that may regulate processes such as catalytic function, substrate phosphorylation, or serve as regulatory domains. These other domains are often evolutionarily divergent across the kinase superfamily and provide unique handles fo

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Novel Peptide-Based Inhibitors of Protein Kinases,y aspects of cellular metabolism including signal transduction, transcription, translation, cell-cycle progression, and biosynthesis. Owing to their profound influence over such critical cellular processes, mutations or aberrant expression of protein kinases can have major implications on cell healt

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Paul Shapiro,Ramon Martinez III,Amy Defnetory protocols complete with lists of materials and vital notOver the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation.In Suppression and Regulation of Immune Responses: Methods and Protocols, expert researchers

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Ramon Martinez III,Amy Defnet,Paul Shapiroory protocols complete with lists of materials and vital notOver the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation.In Suppression and Regulation of Immune Responses: Methods and Protocols, expert researchers